Abstract: OBJECTIVE To investigate the value of color Doppler ultrasound in the diagnosis of infantile hepatitis syndrome caused by infection, so as to provide guidances for clinical diagnosis. METHODS A total of 62 infected patients with infantile hepatitis syndrome in the hospital from Feb. 2012 to Jul. 2016 were selected as research objects, and were set as observation group. Another 30 cases of healthy infants were selected as control group. Two groups of infants were examined by color Doppler ultrasound. The blood flow parameters of the portal vein (PV), the parameters of the hepatic artery (HA) and the diameters of the left, middle and right hepatic veins were compared. RESULTS The vascular PV trunk diameter (DPV) and the maximum blood flow velocity (PVV) of observation group were (0.52±0.03) cm and (25.32±2.06) cm/s, which were higher than (0.43±0.04) cm and (21.56±1.75) cm/s of control group respectively. The results showed that, compared with the normal infants, the DPV increased, and PVV was faster in the infants with the infantile hepatitis syndrome caused by infection , and the difference between the two groups was statistical significance (P<0.05). In observation group, the liver artery diameter (DPHA) was (0.16±0.03) cm, peak systolic blood flow velocity (PSV) was (62.50±9.61) cm/s, and resistance index (RI) was (0.78±0.04), which were significantly higher than (0.14±0.02) cm, (39.91±5.79) cm/s, and (0.64±0.03) of control group the results showed that compared with normal infants, DPHA and RI increased, and PSV was faster in the infants with the infantile hepatitis syndrome caused by infection, and the difference between the two groups was statistical significance (t=3.3083,11.8561,16.9796, P<0.05). There was no significant difference in diastolic blood flow (EDV) between the two groups(t=1.2806,0.2036). In observation group, the diameters of the left, middle and right hepatic veins were (0.19 + 0.01) cm, (0.20±0.03) cm, and (0.23±0.03) cm, which were obviously lower than (0.25± 0.04) cm, (0.29±0.02) cm, and (0.32±0.03) cm of control group respectively. The results showed that compared with normal infants, the diameters of the left, middle and right hepatic veins were significantly smaller in the infants with the infantile hepatitis syndrome caused by infection, and the difference between the two groups was statistical significance(P<0.05). CONCLUSION Color Doppler ultrasound can clearly relate with the hepatitis syndrome conditions of patients, which is an effective and noninvasive method for the diagnosis of infantile hepatitis syndrome caused by infection, and the clinical information is comprehensize, the application value is high, and it is worthy of popularization.