Abstract: OBJECTIV To analyze the clinical features of carbapenem-resistant Klebsiella pneumonia(CRKP) of respiratory tract infection, and explore the prognostic factors of CRKP patients with respiratory tract infection. METHODS From Jan. 2013 to Aug. 2016, the clinical isolates of respiratory specimens from CRKP patients were collected and analyzed. The drug resistance was analyzed with WHONET software. The clinical data of CRKP patients were analyzed by univariate analysis and multivariate Logistic regression analysis. RESULTS There were 98 strains of CRKP detected from 745 strains of non repetitive respiratory tract infection isolates of K. pneumonia, with detection rate of 13.15%. From 2013 to 2015, the resistant rates to carbapenem were 0.95%, 7.34% and 22.99%, which was increased year by year, and the difference was significant (P< 0.01). The top three departments of CRKP detection rate were ICU, the emergency ward and department of geriatrics. The sensitive rates of CRKP to amikacin and sulfamethoxazole / trimethoprim were high, which were respectively 62.24% and 46.94%. There were 29 cases died in 98 cases, with the mortality rate of 29.59%. Univariate analysis showed that patients with chronic obstructive pulmonary disease (P＜0.05), total hospitalization time(P＜0.05) and mechanical ventilation (P＜0.05), catheterization(P＜0.05), central venous catheter (P＜0.05), quinolones (P＜0.05), glycopeptide (P＜0.05), and anti fungal drugs (P＜0.05) were related to the risk of death in patients with CRKP. multivariate regression analysis showed that chronic obstructive pulmonary disease (P＜0.05), catheterization (P＜0.05), and glycopeptide (P＜0.05) were closely related to the mortality rate of patients. CONCLUSION CRKP of respiratory tract infection rate increased year by year. The chronic obstructive pulmonary disease, use of indwelling catheter, and use of glycopeptide antibiotics are independent risk factors for death.