Abstract: OBJECTIV To investigate the characteristics of multidrug-resistance included by three admission methods of elderly patients with stroke-related pneumonia and put forward the intervention measures so as to prevent the cross infection and improve the effect of treatment of infection, as well as the medical quality. METHODS A total of 707 elderly patients with stroke-related pneumonia who were treated from Jan 2014 to Jan 2016 were enrolled in the study. 373 patients who were admitted from outpatient department were assigned as the outpatient transferred group, 74 patients who were admitted outside the hospital were assigned as outer hospital transferred group, and 260 patients who were admitted inside the hospital were set as the inner hospital transferred group. The positive rate of drug-resistant bacteria, incidence of nosocomial infections, and distribution of top 4 species of drug-resistant bacteria were observed and compared among the three groups. RESULTS The positive rate of drug resistant bacteria, outside the hospital into the group, into the outpatient group was significantly higher than that of the hospital group (P<0.05), and outside the hospital into the outpatient group was significantly higher than that in group transferred (P<0.05); the rate of nosocomial infections of drug-resistant bacteria, outside the hospital into the hospital outpatient group and the group was significantly higher than that in group transferred (P<0.05), 8~15d, three groups of drug resistant bacteria positive rate was higher than 1~7d, 16d or higher than 8~15d, the differences were significant (P<0.05); outside the hospital into the group and hospital group Acinetobacter bauman infection rate was higher than the others in the group of outpatients antibiotic resistant strains of Klebsiella pneumoniae were higher than the other, the differences were significant (P<0.05) CONCLUSION Among the elderly patients with stroke-related pneumonia, the positive rate of the multidrug-resistance is the highest in the patients who are transferred from outpatient and outer hospital, especially those who are transferred from the outer hospital. It is an effective way to strengthen the surveillance and screening of the drug-resistant bacteria in this group of patients, take effective isolation measures, and choose appropriate antibiotics so as to prevent the nosocomial cross infections and improve the therapeutic effect.