Abstract: OBJECTIV To investigate the epidemiological characteristics of bloodstream infection caused by non-Candida albicans and analyze the related risk factors so as to provide guidance for clinical prevention and treatment. METHODS A total of 91 tumor patients with Candida bloodstream infection who were treated in hospitals from 2007 to 2015 were enrolled in the study, and the medical records of the enrolled patients were retrospectively analyzed. RESULTS Of the 91 tumor patients with Candida bloodstream infection, 49 (53.8%) had C. albicans bloodstream infection and 42 (46.2%) had non-C. albicans infection. The pathogens that resulted in the non-C. albicans bloodstream infection were in turn as follows: C. parapsilosis (21 strains, 23.1%), Candida glabrata (8 strains, 8.8%), Candida tropicalis (7 strains, 7.7%), Candida famata (3 strains, 3.3%), and Candida lusitaniae (3 strains, 3.3%). The 30-day mortality rate of the patients with Candida bloodstream infection was 28.6%, the patients with C. albicans bloodstream infection 26.5%, the patients with non-C. albicans infection 31.0%. As compared with the C. albicans bloodstream infection, the hospitalization duration more than 35 days and tumor distant organ metastasis were the independent risk factors for the non-C. albicans infection. CONCLUSION This study not only interprets the epidemiological characteristics of the Candida bloodstream infection but also defines the independent risk factors for the complication with non-C. albicans bloodstream infection in the tumor patients, which provides theoretical basis for formulating corresponding prevention and treatment measures.