Abstract: OBJECTIV To observe the influence of general anesthesia combined with epidural anesthesia on lung function and postoperative pulmonary infections in patients undergoing gastrectomy. METHODS A total of 200 patients who underwent the gastrectomy in the hospital from Jan 2014 to Dec 2015 were enrolled in the study and divided into the observation group and the control group. The observation group was treated with general anesthesia combined with epidural anesthesia, while the control group was treated with single general anesthesia. The perioperative lung function indexes, time of recovery of anesthesia, incidence of pulmonary infections, and distribution of pathogens causing pulmonary infections were observed and compared between the two groups of patients. RESULTS As compared with the baseline value, the (MVV-VE)/FEV1 and MVV/FEV1 of the control group were significantly lower after the surgery for 1 and 3 days than 1 day before the surgery, the RV/TLC% was remarkably elevated, however, there was no significant change in the baseline value in the observation group before and after the surgery. Three indexes of the observation group were better than those of the control group at the same time points after the surgery. The anesthesia recovery time of the observation group was remarkably shorter than that of the control group, and the incidence of postoperative pulmonary infection was significantly reduced. The gram-negative bacteria were dominant among the pathogens isolated from the patients with pulmonary infection, among which Pseudomonas aeruginosa and Escherichia coli were the predominant species. CONCLUSION The general anesthesia combined with epidural anesthesia has less impact on the lung function of the patients undergoing gastrectomy, and it may reduce the incidence of postoperative pulmonary infection and facilitate the prognosis of the patients.