Abstract: OBJECTIV To observe the application effect of minocycline hydrochloride ointment on infections around implant and effect on control of inflammatory reactions so as to provide guidance for treatment of patients with infection around implant. METHODS A total of 60 patients with infections around implant who were treated in the hospital from Feb 2013 to Apr 2016 were randomly divided into the control group and the observation group, with 30 cases in each group. The control group was treated with conventional therapy for the infections around implant, while the observation group was given additional minocycline hydrochloride ointment based on the treatment of the control group. The total effective rate of treatment was observed and compared between the two groups of patients, the periodontal indexes and gingival crevicular fluid inflammation indexes were statistically analyzed and compared before and after the treatment, and the prevalence of pathogenic bacteria infection in all of the patients was determined. RESULTS The total effective rate of treatment was 100.00% among the 30 patients with infections around implant in the observation group, significantly higher than 86.67% among the 30 patients with infections around implant in the control group. The periodontal indexes of the observation group were better than those of the control group after the treatment for 2 and 4 weeks; the gingival crevicular fluid inflammation indexes of the observation group were lower than those of the control group. Totally 78 strains of pathogens were isolated from the 60 patients; the isolation rate of anaerobic bacteria was significantly higher than that of the aerobic bacteria (P<0.05). CONCLUSION Minocycline hydrochloride ointment shows remarkable effect on treatment of the infection around implant and on control of inflammatory reactions, and it has high application value in treatment of this group of patients.