Abstract: OBJECTIV To explore the pathogen distribution in patients with acute myocardial infarction complicated with nosocomial infections, and analyze the effect of infections on the prognosis of acute myocardial infarction. METHODS A total of 100 patients with acute myocardial infarction complicated with nosocomial infections were selected as observation group, and sputum culture and drug sensitivity test were performed in all patients. Another 100 patients with acute myocardial infarction without nosocomial infections were selected as control group. The effect of infections on the prognosis of acute myocardial infarction was analyzed. RESULTS A total of 128 strains of pathogens were isolated from 100 patients, including 70 strains of gram-negative bacteria(54.7%), which were mainly Klebsiella pneumoniae, and had higher sensitivities to imipenem, cefoperazone / sulbactam and cefotaxime, 38 strains of gram-positive bacteria(29.7%), which were mainly Staphylococcus aureus, and had higher sensitivities to linezolid and vancomycin, and 20 strains of fungi (15.6%), which were mainly Candida albicans, and had a higher sensitivity to voriconazole. The survival rate of observation group was 37%%, which was significantly lower than 70.0% of control group (P<0.05). CONCLUSION Concurrent nosocomial infections seriously affect the living conditions in patients with acute myocardial infarction.