Abstract: OBJECTIV To observe the correlation between the cervical cancer and the female genital tract human papillomavirus, herpes simplex virus type Ⅱ, Chlamydia trachomatis, Trichomonas or bacterial vaginosis infection. METHODS Totally 100 patients with cervical cancer who were treated in the hospital from Jan 2012 to Dec 2015 were chosen as the cervical cancer group, and 100 healthy women who received physical examination were set as the control group. The prevalence of genital tract human papillomavirus, herpes simplex virus type Ⅱ, C.trachomatis, trichomonas or bacterial vaginosis infection was detected. RESULTS The incidence rate of the genital tract human papillomavirus, herpes simplex virus type Ⅱ, C.trachomatis, trichomonas or bacterial vaginosis infection was higher in the cervical cancer group than in the control group (P<0.05). The detection rate of high-risk human papillomavirus of the cervical cancer group was significantly higher than that of the control group, and there was significant difference (P<0.05). The incidence rate of human papillomavirus mixed with C.trachomatis, human papillomavirus mixed with trichomonas, or human papillomavirus mixed with bacterial vaginosis infection was significantly higher in the cervical cancer group than in the control group (P<0.05). The high-risk human papillomavirus infection was positively correlated with the C.trachomatis, Trichomonas and bacterial vaginosis infection, and there was significant difference (P<0.05). CONCLUSION The incidence of cervical cancer is associated with the genital tract infection. The patients with high-risk human papillomavirus infection are dominant among the cervical cancer patients with genital tract infection. The high-risk human papillomavirus infection is positively correlated with the C.trachomatis, Trichomonas or bacterial vaginosis infection.