Abstract: OBJECTIV To analyze the risk factors for nosocomial infections in hospitalized children of pediatrics department and explore the prevention and control measures to reduce the incidence of nosocomial infections in the hospitalized children so as to improve the quality of treatment of the hospitalized children of pediatrics department. METHODS A total of 2763 children who were hospitalized for treatment in the pediatrics department from Jan 2013 to Oct 2016 were enrolled in the study. The clinical data and admission and treatment status were statistically analyzed, the univariate analysis and multivariate logistic analysis were performed to analyze the risk factors for nosocomial infections in the hospitalized children of pediatrics department, and the countermeasures for prevention and control of nosocomial infections in the hospitalized children of pediatrics department were explored. RESULTS Of the 2763 children, 105 had nosocomial infection, with the infection rate 3.80%. The related factors for the nosocomial infection in the hospitalized children of pediatrics included less than 3 years of age, poor nutritional status, infections at admission, hospitalization duration more than 5 days, use of no less than 3 types of antibiotics, time of use of antibiotics more than 3 days, use of hormones during treatment, and invasive operation. The multivariate Logistic analysis showed that the independent risk factors for the nosocomial infection in the hospitalized children of pediatrics department included the less than 3 years old (OR=1.485), poor nutritional status(OR=1.285), infection at admission(OR=4.584), hospitalization duration more than 5 days (OR=2.287), use of no less than 3 types of antibiotics(OR=3.820), time of use of antibiotics more than 3 days(OR=1.752), use of hormones during treatment(OR=1.842), and invasive operation(OR=1.726). CONCLUSION There are a variety of risk factors for the nosocomial infections in the hospitalized children of pediatrics department,and it is necessary for health care workers to take the prevention measures from multiple aspects.