Abstract: OBJECTIVE To explore the risk factors and etiological characteristics of postoperative incision infections in patients with ovarian cancer and analyze the drug resistance so as to provide guidance for clinical prevention and treatment of the ovarian cancer patients with postoperative incision infections.METHODS A total of 473 patients with ovarian cancer who were treated in Zhejiang Cancer Hospital from Jan 2012 to Dec 2015 were enrolled in the study, all of the patients received ovarian cancer cytoreductive surgery, the incidence of postoperative incision infections and risk factors were analyzed, and the distribution and drug resistance of pathogens were observed.RESULTS Of the 473 ovarian cancer patients, 25 had the postoperative incision infections, with the infection rate 5.29%. Multivariate logistic regression analysis indicated that the stage Ⅲ or Ⅳ of FIGO, diabetic mellitus, and allogeneic blood transfusion were the risk factors for the postoperative incision infections in the ovarian cancer patients (P＜0.05).A total of 32 strains of pathogens were isolated, including 14 (43.75%) strains of gram-positive bacteria and 18 (56.25%) strains of gram-negative bacteria.Staphylococcus aureus and Escherichia coli were the most common species of pathogens, accounting for 25.00% and 28.13%, respectively.The S.aureus strains were highly resistant to penicillin G, ciprofloxacin, and nitrofurantoin; the E.coli strains were highly resistant to cefotetan, sulfamethoxazole-trimethoprim, and ampicillin.CONCLUSIONThe stage Ⅲ or Ⅳ of FIGO, diabetic mellitus, and allogeneic blood transfusion are the risk factors for the postoperative incision infection in the patients with ovarian cancer.The gram-negative bacteria are dominant among the pathogens causing the infections and are highly resistant to antibiotics.