Abstract: OBJECTIVE To explore the distribution of pathogens causing central venous catheter-guided catheter infections in breast cancer patients and analyze the related risk factors so as to understand the features of the pathogens and the risk factors for the central venous catheter-guided catheter infections in the breast cancer patients.METHODS A total of 210 breast cancer patients who received central venous catheter-guided catheterization chemotherapy in the hospital from Feb 2013 to Jan 2015 were enrolled in the study.The data of the patients, including age, sites of central venous catheter-guided catheterization, puncture sites, types of infection, length of hospital stay, related risk factors, and distribution and drug resistance of pathogens, were recorded in detail.RESULTS The catheter-related bloodstream infections were associated with the season of puncture, complications, cycle of maintenance of catheter, movement of catheter, and immune function (P＜0.05); the complications, cycle of maintenance of catheter, movement of catheter, and immune function were the independent risk factors for the central venous catheter-guided catheter infections in the breast cancer patients (P＜0.05).Of the 210 breast cancer patients, 32 had the central venous catheter-guided catheter infections.Totally 46 strains of pathogens were isolated, including 24 (52.2%) strains of gram-negative bacteria, 15 (32.6%) strains of gram-positive cocci, and 7 (15.2%) strains of fungi; Pseudomonas aeruginosa and Acinetobacter baumannii were dominant among the gram-negative bacteria; Staphylococcus aureus was the predominant species of the gram-positive cocci; Candida albicans and Candida tropicalis were dominant among the fungi.The pathogens isolated from the breast cancer patients with central venous catheter-guided catheter infections were highly resistant to antibiotics, especially the commonly used antibiotics such as penicillin, cefazolin, and amoxicillin; the drug resistance rates of the gram-positive bacteria and gram-negative bacteria were more than 80.0%; however, the drug resistance rates of the fungi to fluconazole, itraconazole, and amphotericin B were less than 40.0%.CONCLUSIONIt is necessary for the hospital to carry out standard operations, create comfortable sanitary environment, and enhance the patients' immunity so as to reduce the incidence of the central venous catheter-guided catheter infections. The drug susceptibility testing must be carried out as the patients with the infections are given the antibacterial therapy, and the highly sensitive, safe antibiotics should be chosen based on the result of the drug susceptibility testing so as to avoid the emergence of drug-resistant strains and improve the prognosis of the patients.