Abstract: OBJECTIVE To explore the causes of clinical missed diagnosis of pulmonary infections in patients with Parkinson's disease and observe the distribution and drug resistance of pathogens so as to reduce the missed diagnosis rate and infection rate.METHODS A total of 86 Parkinson's disease with pulmonary infections who were treated in the hospital from Jan 2011 to Jan 2013 were retrospectively analyzed.The distribution and drug resistance of the pathogens were statistically analyzed, and the causes of the missed diagnosis of 11 patients were summarized.RESULTS Totally 107 strains of pathogens were isolated from the 86 Parkinson's disease with pulmonary infection, including 72 (67.29%) strains of gram-negative bacteria and 35 (32.71%) strains of gram-positive bacteria. Among the gram-negative bacteria, Pseudomonas aeruginosa accounted for 28.97%, Escherichia coli 17.76%, Enterobacter cloacae 12.15%. Among the gram-positive bacteria, Staphylococcus aureus accounted for 15.89%, Streptococcus pneumoniae 10.28%.The drug resistance rates of the gram-negative bacteria to imipenem and meropenem were 0, and the drug resistance rates to the rest of antibiotics were more than 52.63%.The drug resistance rate of the gram-positive bacteria to vancomycin was 0, and the drug resistance rates to the rest of antibiotics were more than 72.73%.The oral administration of drugs was the most common cause of missed diagnosis of pulmonary infection in the Parkinson's disease patients, accounting for 36.37%, followed by the withdrawal, insufficiency, or reduction of drugs (27.27%), aspiration (18.18%), and doctors' neglection (18.18%).CONCLUSIONThere are a variety of species of pathogens causing the pulmonary infections in the patients with Parkinson's disease.The missed diagnosis rate is high, and most of the causes are subjective.