Abstract: OBJECTIVE To explore the distribution and drug resistance of pathogens isolated from pulmonary heart disease patients complicated with respiratory tract infections so as to provide guidance for development of antibacterial programs.METHODS The clinical data of 218 pulmonary heart disease patients complicated with respiratory tract infections who were treated in the hospital from Jan 2013 to Nov 2016 were retrospectively analyzed, the result of sputum culture was analyzed, and the distribution of pathogens and the drug resistance rates to the commonly used antibiotics were statistically analyzed.RESULTS Totally 338 times of sputum specimens were submitted from 8 patients; a total of 303 strains of pathogens were isolated, of which 151 (49.84%) were gram-negative bacteria, 80 (26.40%) were gram-positive bacteria, and 72 (23.76%) were fungi.Totally 20 case-times of patients had double infections, and 39 patients had mixed infections.The gram-positive bacteria were highly resistant to erythromycin and clindamycin, the drug resistance rate more than 80.00%, but were highly susceptible to vancomycin; the drug resistance rates of Staphylococcus aureus, Staphylococcus haemolyticus, and Staphylococcus epidermidis to penicillin, cefazolin, and ceftriaxone were more than 70.00%.The drug resistance rates of the gram-negative bacteria to cefepime and cefotaxime were more than 50.00%, the drug resistance rate of Pseudomonas aeruginosa was more than 30.00% to all of the commonly used antibiotics except for tazobactam; Klebsiella pneumoniae was highly susceptible to ciprofloxacin and meropenem; Escherichia coli was highly susceptible to imipenem and meropenem; the drug resistance rate of Acinetobacter baumannii was more than 50.00% to all of the commonly used antibiotics except for gentamicin.CONCLUSIONThe gram-negative bacteria are dominant among the pathogens isolated from the pulmonary heart disease patients complicated with respiratory tract infection and are highly resistant to antibiotics.It is necessary for the hospital to further standardize the use of antibiotics so as to reduce the drug-resistant strains.