Abstract: OBJECTIVE To explore the effect of fiberoptic bronchoscopy lavage on treatment of mechanical ventilation patients with pulmonary infections.METHODS A total of 72 pulmonary infection patients complicated with respiratory failure who received mechanical ventilation in intensive care unit from Jun 2013 to Jun 2016 were enrolled in the study and divided into the observation group and the control group, with 36 cases in each.The control group was given comprehensive therapies such as conventional anti-infection, expectorant, antispasmodic, and relieving asthma, while the observation group was treated with additional daily Fiberoptic bronchoscopy sputum suction and local bronchoalveolar lavage based on the treatment of the control group.The levels of arterial blood gases, white blood cell (WBC) counts, high-sensitive CRP (hs-CRP), and procalcitonin (PCT) were observed and compared between the two groups of patients after the treatment for 3 days; the time of body temperature returning to normal, mechanical ventilation duration, length of ICU stay, total effective rate of treatment, and satisfaction were compared between the two groups of patients.RESULTS Both PaO₂ and oxygenation index of the two groups of patients were elevated after the treatment for 3 days; the PaO₂ of the observation group was (83.23±12.59)mmHg, higher than (77.45±8.59)mmHg of the control group, and the oxygenation index of the observation group was 190.23±21.56, significantly higher than 168.78±22.59 of the control group(P＜0.05).The PaCO₂ of the two groups of patients declined, the PaCO₂ of the observation group was (38.65±7.12)mmHg, lower than (45.17±6.03)mmHg of the control group (P＜0.05). The levels of WBC, hs-CRP, and PCT of the two groups of patients were reduced and were significantly lower in the observation group than in the control group (11.74±2.76 vs 13.89±2.15, 73.26±11.65 vs 82.13±13.57, 0.53±0.39 vs 0.92±0.45),(P＜0.05).The time of body temperature returning to normal (2.78±0.56) days, mechanical ventilation duration (9.45±4.38) days, and length of ICU stay (12.12±3.60) days of the observation group were significantly shorter than those of the control group(4.12±0.92) days, (12.23±5.89) days, (18.23±3.02) days, (P＜0.05).The total effective rate of treatment of the observation group was 97.22%, significantly higher than 69.44% of the control group(P＜0.05).CONCLUSIONThe conventional fiberoptic bronchoscopy lavage can effectively improve the oxygenation of the pulmonary infection patients complicated with respiratory failure and shorten the mechanical ventilation, with the effect remarkable, and it is worthy to be promoted in the hospital.