Abstract: OBJECTIVE To observe the efficacy and safety of standard triple therapy plus Pudilan anti-inflammatory oral solution in treatment of gastritis induced by Helicobacter pylori infection so as to provide guidance for clinical treatment.METHODS A total of 100 children with H.pylori gastritis who were treated in hospitals from Jan 2015 to Aug 2016 were enrolled in the study and were randomly divided into the control group and the treatment group according to the serial number of treatment, with 50 cases in each group.The treatment group was treated with standard triple therapy plus Pudilan, with 14 days a treatment course; the control group was given the standard triple therapy, with 14 days a treatment course.The status of improvement of clinical symptoms and clearance rate of H.pylori were compared between the two groups of patients after one treatment course, the drug-induced adverse reactions were observed during the treatment process; the efficacy and safety of the standard triple therapy plus Pudilan anti-inflammatory oral solution in treatment of the children with gastritis induced by Helicobacter pylori infection were analyzed.RESULTS The children of both groups completed the established treatment plans.The clearance rate of H.pylori of the treatment group was 86.0%, higher than 76.0% of the control group, and there was no significant difference.The rates of improvement of abdominal pain, nausea, vomiting and heavy breath symptoms were significantly higher in the treatment group than in the control group, and there was between-group difference (P＜0.05).The children of the treatment group had skin rash and diarrhea during the treatment, and the children of the control group had diarrhea, the incidence of diarrhea of the treatment group was higher than that of the control group, however, there was no between-group difference.CONCLUSIONThe standard triple therapy plus Pudilan anti-inflammatory oral solution, with 14 days a treatment course, can not remarkably raise the clearance rate of the H.pylori but can remarkably improve the digestive tract symptoms without significant increase of adverse reactions, indicating that the method has more advantages than the single standard triple therapy; it is necessary to expand the scope of study and standardize the treatment plans so as to improve the quality of life of the children.