Abstract: OBJECTIVE To explore the clinical value of infection probability score (IPS), procalcitonin (PCT) and C-reactive protein (CRP) in prediction of postoperative incision infections in patients undergoing lateral episiotomy so as to provide guidance for prevention and treatment of the postoperative incision infections. METHODS A total of 200 parturient women who were hospitalized from Jan 2016 to Dec 2016 were enrolled in the study, the IPS of the study objects was analyzed, the blood PCT and CRP were determined, the incidence of postoperative incision infection was observed, and the local secretions specimens that were collected from the study objects with incision were cultured. RESULTS Of the 200 parturient women, 18 had postoperative incision infections, with the infection rate 9.00%, of whom 13 were cultured positive for pathogens, with the positive rate of culture of pathogens 72.22%. Totally 13 strains of pathogens were isolated, of which 7 (53.85%) were Escherichia coli. The IPS, PCT and CRP of the parturient women with infections were respectively (8.12±4.20)points, (0.06±0.03)ng/ml and(6.43±1.61)mg/L, higher than (5.10±2.41)points, (0.04±0.01)ng/ml and (5.19±0.97)mg/L of the parturient women without infection, and there was significant difference (P<0.05). The incidence of postoperative incision infections was 4.22% in the parturient women at low risk of preoperative IPS, 32.35% in the parturient women at high risk of preoperative IPS; the incidence of postoperative incision infections was 2.78% in the parturient women with negative preoperative PCT, 25.00% in the parturient women with positive preoperative PCT; the incidence of postoperative incision infections was 4.76% in the parturient women with negative preoperative CRP, 16.22% in the parturient women with positive preoperative CRP, and there was significant difference (P<0.05). CONCLUSION The risk of postoperative incision infection is remarkably increased in the parturient women with high IPS, PCT and CRP before the lateral episiotomy. The IPS, PCT and CRP have certain clinical value in prediction of the postoperative incision infections in the parturient women undergoing the lateral episiotomy.