Abstract: OBJECTIVE To sinvestigate clinical values of serum procalcitonin(PCT), serum amyloid protein A(SAA) and interleukin-8(IL-8) in the diagnosis of ascites infections in patients with cirrhosis, so as to provide references for the diagnosis of ascites infection in patients with cirrhosis. METHODS A total of 100 cases of ascites patients with cirrhosis treated in the hospital from Jan. 2015 to Dec. 2016 were selected, and were divided into infection group(32 cases) and non-infection group(68 cases) according to whether the patient had ascites infections. After admission, the ascites was puncture extraction for bacterial culture, and the peripheral blood samples were drawn for detection of serum PCT, SAA and IL-8. RESULTS Among 100 cases of patients, 32 cases were germiculture positive in ascites, and the positive rate was 32.00%. Totally 35 strains of pathogenic bacteria were cultured in 32 cases of patients, including 23 strains of gram-positive bacteria(65.71%) and 12 strains of gram-negative bacteria(34.29%). The PCT, SAA and IL-8 of infection group were (5.22±1.25)ng/ml, (35.51±8.12)mg/L and (18.49±3.40)pg/ml, which were significantly higher than (0.17±0.18)ng/ml, (4.19±0.27)mg/L and (10.20±2.34)pg/ml of non-infection group (P<0.05).Using ascites germiculture positive as the gold standard, the sensitivities of serum PCT, SAA and IL-8 were 96.88%, 93.75% and 87.50% in the diagnosis of ascites infection, the specificities were 88.24%, 79.41% and 82.35%,AUC were 0.924, 0.912 and 0.903, and precisions were 91.00%,84.00% and 84.00%, respectively. CONCLUSION Serum PCT, SAA and IL-8 levels increase in the ascites infection in patients with cirrhosis, which has high sensitivity and specificity in the auxiliary diagnosis of ascites infections. For patients with no obvious symptoms of ascites infections, if the serum levels of PCT, SAA and IL-8 are incresed, early intervention should be recommended.