Abstract: OBJECTIVE To explore the clinical effect of concurrent radiotherapy and chemotherapy in the treatment of advanced cervical cancer, and analyze risk factors of local infections of cervical cancer. METHODS A total of 60 patients with advanced cervical cancer from Jan. 2010 to Jan. 2011 in our hospital were randomly divided into observation group and control group, with 30 cases in each group. Patients in control group were given radiotherapy alone, and in observation group were given concurrent radiotherapy and chemotherapy. The short-term efficacy and adverse reaction of the two groups were compared. Patients were followed up for 5 years, and the short-term and long-term efficacy between the two groups were compared. Infection related factors were analyzed. RESULTS The total efficacy in observation group was 93.33%, which was significantly higher than 73.33% in control group (P<0.05). The 5-year survival rate in observation group was 76.67%, which was significantly higher than 53.33% in control group (P<0.05). The local recurrence rate and distant metastasis rate in observation group were respectively 16.67% and 13.33%, which were significantly lower than 33.33% and 26.67% in control group (P<0.05). The adverse reaction rate in control group was 13.33%, compared with 23.33% in observation group, the difference was not significant. There were 20 cases of local infections in observation group, and the infection rate was 66.67%. The hospitalization time>7d, with underlying diseases, unskilled operation of medical personnel, catheter indwelling time >3d, without the use of antibiotics and FIGO stage of IVb were independent risk factors of concurrent local infections in cervical cancer patients with cavity radiotherapy (P＜0.05). CONCLUSION The efficacy of concurrent radiotherapy and chemotherapy for patients with advanced cervical cancer is relatively good, which can improve the survival rate of patients, and has better tolerance.