Abstract: OBJECTIVE To analyze the characteristics of multidrug-resistant Acinetobacter baumanii (MDRAB) bloodstream infections, and to screen the risk factors of MDRAB bloodstream infection. METHODS A total of 294 patients with bloodstream infections enrolled in our hospital from Aug. 2013 to Dec. 2016 were selected. Among them, 227 cases were of non-MDRAB bloodstream infections, and 67 cases were of MDRAB bloodstream infections. The clinical characteristics of MDRAB patients with bloodstream infections were analyzed and summarized, and the risk factors of MDRAB bloodstream infection were identified by multivariate regression analysis. RESULTS Univariate analysis showed that the no less than 60 years of age, combined with respiratory failure, with hypoalbuminemia , with organ failure, entering ICU, APACHE Ⅱ score> 20 points, accepting mechanical ventilation, prophylactic use of antibiotics, and deep vein invasive operation were the risk factors of MDRAB bloodstream infections (P<0.05). Multivariate regression analysis showed that combined with organ failure, entering ICU, APACHE Ⅱ score, accepting mechanical ventilation, prophylactic use of antibiotics, and deep vein invasive operation were the independent risk factors for MDRAB infections (P<0.05). The results of drug resistance analysis of 88 strains of MDRAB showed that the resistant rates of MDRAB to cefuroxime, amoxicillin and amikacin were high, and to minocycline and cefoperazone sulbactam was low. CONCLUSION MDRAB is sensitive to minocycline and cefoperazone sulbactam. It is recommended to pay attention to the prevention and treatment of MDRAB bloodstream infections, and to select high sensitivity drugs to improve the prognosis.