Abstract: OBJECTIVE To observe the tangible impact of WeChat public number-based training of interns on prevention and control of nosocomial infections so as to provide the theoretical basis for construction of scientific, reasonable and localized training mode of foreign-related nursing talents.METHODS A total of 102 nursing interns who had their internships in a three-A hospital of Zhengzhou from Feb 2014 to Apr 2016 were recruited as the study objects and divided into two groups; 51 nursing interns who received conventional internship training were assigned as the control group, and the rest of 51 nursing interns who received WeChat public number-assisted training were set as the experimental group. The nursing interns were evaluated based on 4 aspects, including the actual operation performance, professional degree of diagnosis and treatment, accuracy of diagnosis of diseases and mastery degree of disinfection procedures, and they were finally assessed at the end of their internships. The awareness rate and implementation rate of related measures for control of infections were compared between the two groups of interns; the nosocomial infection health indexes such as qualified rate of use of instruments, qualified rate of hand hygiene, degree of air cleanliness and qualified rate of disinfection were observed and compared between the two groups during the internship.RESULTS The scores of actual operations, professional degree of diagnosis and treatment, accuracy of diagnosis and nursing and disinfection operation were higher in the experimental group than in the control group during the training. In regard to the final assessment, the score of the interns was (57.15±13.54) points in the experimental group, (44.87±11.35) points in the control group, and there was significant difference between the two groups (P＜0.05). The qualified rates of use of instruments, hand hygiene, air cleaning and disinfection of the experimental group were higher than those of the control group, and there were significant differences between the two groups (P＜0.05). The result of self-designed questionnaire survey showed that the mastery degree of basic information of nosocomial infection and awareness rate of infection control measures were higher in the experimental group than in the control group after the training, and there were significant differences (P<0.05).CONCLUSION WeChat public number-based training may effectively raise the interns' cognition about infection-related knowledge and improve the compliance of prevention and control measures so as to reduce the risk of infections, and the training has achieve remarkable effect. As a scientific, reasonable and localized training mode of foreign-related nursing talents, WeChat public number-based training is worthy to be promoted in hospitals.