Abstract: OBJECTIVE To investigate the etiological characteristics and drug resistance of postoperative infections in patients with cervical cancer, so as to provide evidence for clinical treatment. METHODS The clinical data of 274 patients with cervical cancer who underwent radical resection of cervical cancer in our hospital from Jan. 2012 to Jan. 2017 were retrospectively analyzed. The isolates were identified by automatic bacterial analyzer, and the resistance of pathogens to antibiotics was detected by disk diffusion (K-B) method. The pathogens and drug resistance of nosocomial infections after operation were observed and analyzed. RESULTS Among 274 patients underwent radical resection of cervical cancer, there were postoperative hospital infections in 58 cases, and the postoperative nosocomial infection rate was 21.17%. The main infection sites were urinary tract and surgical incision, accounting for 36.21% and 27.59%. A total of 86 strains of pathogenic bacteria were isolated from 58 cases of nosocomial infections, including 48 strains of gram-negative bacteria (accounting for 55.81%), 32 strains of gram-positive bacteria (accounting for 37.21%), and 6 strains of fungi (accounting for 6.98%). The resistant rates of main gram-negative bacteria to sulfamethoxazole/trimethoprim, tetracycline and amoxicillin were high, which were more than 80%. The resistant rates of Enterococcus faecalis to chloramphenicol, tetracycline and rifampicin were high, which were higher than 50%. The resistant rates of Staphylococcus epidermidis to gentamicin, penicillin G and levofloxacin were high, which were higher than 60%. CONCLUSION The incidence of nosocomial infections after surgery radical resection of cervical carcinoma is high, and the pathogenic species are complex with strong resistance, so clinical treatment should select rational antimicrobial agents based on the results of drug sensitivity test, so as to improve the curative effect of clinical treatment and control the nosocomial infections.