Abstract: OBJECTIVE To investigate the characteristics and risk factors of intracranial infections after operation in patients with brain glioma. METHODS A total of 94 patients with brain glioma in hospital from Jan. 2008 to Dec. 2016 were selected. The distribution of pathogens in cerebrospinal fluid, antimicrobial resistance and risk factors of infection in patients with intracranial infections were analyzed. RESULTS Totally 13 cases of intracranial infections were found in 94 patients with brain glioma, and the infection rate was 13.83%. Totally 36 strains of pathogenic bacteria were isolated and cultured, among which 22 cases were gram-positive bacteria, accounting for 61.11%, and 14 cases were gram-negative bacteria, accounting for 38.89%. Gram positive bacteria Staphylococcus aureus had high resistant rate to erythromycin, penicillin and tetracycline, which were 100.00%, 90.00% and 70.00%, respectively; and Staphylococcus epidermidis had high resistant rate to penicillin, tetracycline and erythromycin, which were 100.00%, 87.50% and 75.00% respectively. Gram-negative bacteria Klebsiella pneumoniae had high resistant rate to cefuroxime and ampicillin, which were both 83.33%; and Acinetobacter baumannii had high resistant rate to ampicillin and cefuroxime, which were respectively 100% and 80%. Age, duration of surgery and prophylactic antibiotics were independent risk factors for postoperative intracranial infections (P＜0.05). CONCLUSION The pathogens of postoperative intracranial infections in patients with brain glioma were mainly gram-positive bacteria. Rational use of antibiotics should be taken according to drug sensitivity, and risk factors for infection should be paid attention in order to reduce the infection rate.