Abstract: OBJECTIVE To investigated the clinical characteristics and risk factors for mortality of malignancy patients with nosocomial Enterococcus faecium bloodstream infections (BSI). METHODS The clinical data of malignancy patients with nosocomial E. faecium BSI were collected from Jan. 2012 to Dec. 2015. The risk factors for mortality were analyzed by logistic regression analysis. RESULTS There were 93 malignancy patients enrolled in this study. The main tumor types were solid tumors which accounting for 82 cases (88.17%). There were 86 cases (92.47%) of these patients with fever, 56 cases (65.12%) with chill; 84 cases (90.32%) with leukocytes and/or granulocytes increased, and 89 cases (95.70%) with C-reactive protein increased. Most of the patients (61 cases, 65.59%) were secondary bloodstream infections. Drug sensitivity results showed, resistant rate to vancomycin was 5.63%. All these E. faecium isolates were sensitive to both teicoplanin and linezolid. The 30-day mortality rate was as high as 26.88%. The univariate analysis showed that enrolled in ICU, renal function insufficiency, CCI score, APACHEⅡ score, secondary BSI, surgery at 30 days before the onset, chemotherapy, mechanical ventilation, tracheal intubation/tracheotomy and indwelling catheter were associated with the mortality (P <0.05). Multivariate logistic regression analysis showed that only APACHEⅡ score was associated with the mortality (P<0.001). CONCLUSION The clinical features of malignancy patients with nosocomial E. faecium BSI include fever, chill, leukocytes and/or granulocytes increased, and C-reactive protein increased. These isolates are sensitive to vancomycin, teicoplanin and linezolid. For malignancy patients with nosocomial E. faecium BSI, high APACHEⅡ score is an independent risk factor for the mortality.