Abstract: OBJECTIVE To investigate the incidence of nosocomial infections (NI) in burn patients of burns and plastic surgery department and related factors for the NI and observe the distribution and drug susceptibility of pathogens.METHODS A total of 85 burn patients who were treated in wards of burns and plastic surgery department from Jan 2014 to Jan 2017 were retrospectively enrolled in the study. The distribution and drug susceptibility rates of pathogens causing the infections were observed.RESULTS Of the 85 burn patients, 61 had NI, with the infection rate 71.8%. Totally 78 strains of pathogens were isolated from the 61 patients, 64 (82.0%) of which were gram-negative bacteria, 12 (15.4%) were gram-positive bacteria, and 2 (2.6%) were fungi. The drug susceptibility rate of Pseudomonas aeruginosa strains to meropenem was the highest (94.1%), and the drug susceptibility rate of Acinetobacter baumannii strains to netilmicin was the highest (81.5%). Multivariate logistic regression analysis indicated that TBSA more than 40%, full-thickness burns, no less than 65 years of age and inhalation injury were defined as the related factors for the NI.CONCLUSION There are a variety of related factors for the NI in the burn patients, and the P.aeruginosa is the most common species of pathogen causing the NI.