Abstract: OBJECTIVE To explore the influence of early enteral nutrition and parenteral nutrition on C-reactive protein (CRP) level and incidence of nosocomial infections in patients with stress ulcer (SU). METHODS A total of 98 SU patients who were treated in hospitals from May 2014 to Apr 2016 were recruited as the study objects and randomly divided into the enteral nutrition group and the parenteral nutrition group, with 49 cases in each group, which were respectively given early enteral nutrition and parenteral nutrition on basis of conventional treatment.The effective rate of clinical treatment, serum CRP level, pH of gastric juice and incidence of nosocomial infections were observed and compared between the two groups of patients. RESULTS The effective rate of treatment of the enteral nutrition group was 87.8%, significantly higher than 69.4% of the parenteral nutrition group (P＜0.05).There was no significant difference in the CRP or pH value of gastric juice between the two groups of patients before the treatment; after the treatment, the CRP level of the two groups of patients was reduced, while the pH value of gastric juice of the two groups of patients was increased, the amplitude of reduced CRP level of the enteral nutrition group was significantly greater than that of the parenteral nutrition group, and the amplitude of increased pH value of gastric juice of the enteral nutrition group was greater than that of the parenteral nutrition group (P＜0.05).The incidence rate of nosocomial infection was 12.2% in the enteral nutrition group, remarkably significantly than 32.7% in the parenteral nutrition group (P＜0.05). CONCLUSION The early enteral nutrition may improve the curative effect of the SU patient, raise the pH value of gastric juice, alleviate the inflammatory response and reduce the CRP level as well as the incidence of nosocomial infections, and it is worthy to be promoted in the hospital.