Abstract: OBJECTIVE To explore the survival status of prosthesis of patients with peripheral infections of knee joint prosthesis after revision surgery, observe the therapeutic effect and analyze the related influencing factors so as to provide guidance for clinical treatment. METHODS A total of 82 patients with peripheral infections of knee joint prosthesis who were treated in the hospital from Jan 2006 to Jan 2016 were recruited as the study objects and divided into the survival group with 58 cases and the reinfection group with 24 cases according to the status of prosthesis infections, the baseline data of the patients were retrospectively analyzed, the peripheral specimens of prosthesis of the patients with infections were collected for bacterial culture and identification, the routine indexes such as procalcitonin (PCT), C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were compared between the two groups of patients, and the sense of pain and motor function were evaluated and analyzed by using visual-analogue scale (VAS) and motor function evaluation scale (including exercise capacity and joint motion capabilities). RESULTS There was no significant difference in the age or disease course between the survival group and the re-infection group; there were significant differences in underlying diseases between the two groups (P＜0.05).The levels of PCT, CRP and ESR of the reinfection group were significantly higher than those of the survival group(P＜0.05).The scores of exercise capacity and joint motion capabilities of the survival group were significantly higher than those of the reinfection group, the degree of pain feeling of the reinfection group was significantly higher than that of the survival group, the VAS score of the reinfection group was significantly higher than that of the survival group(P＜0.05).Totally 43 strains of pathogens were isolated from joint secretions around prosthesis of the patients with infections, among which Staphylococcus aureus and Staphylococcus epidermidis were dominant. CONCLUSIONThe survival status of prosthesis of the patients with peripheral infections of knee joint prosthesis who receive revision surgery is associated with the underlying diseases, exercise capacity and joint motion capabilities.The detection of the routine indexes such as PCT, CRP and ESR may effectively predict the survival status of prosthesis of the patients with peripheral infections of knee joint prosthesis after revision surgery.