Abstract: OBJECTIVE To explore the clinical effect of improved postural drainage of sputum on patients with pulmonary infections after cardiothoracic surgery. METHODS From Sep 2014 to Aug 2016, a total of 92 patients who had pulmonary infections after cardiothoracic surgery were enrolled in the study and randomly divided into the experimental group and the control group, with 46 cases in each group.The control group was treated with conventional therapy and conventional postural drainage, while the experimental group was given the conventional therapy and the improved postural drainage, and the curative effects were compared between the two groups of patients after the treatment for 2 weeks. RESULTS There was no significant difference in the partial pressure of arterial oxygen (PaO₂), partial pressure of arterial carbon dioxide (PaCO₂), positive rate of sputum culture, sputum volume or deoxidation time between the two groups of patients before the treatment.The PaO₂, PaCO₂, positive rate of sputum culture, sputum volume and deoxidation time were respectively (91.26±7.21)mmHg, (35.33±3.23)mmHg, 8.7%, (212.3±25.4)ml/d and (15.67±2.32)min/d in the experimental group after the treatment for 2 weeks(P＜0.05).The time of use of antibiotics of the experimental group was (11.42±1.21) days, significantly shorter than the control group (P＜0.05).The proportion of the patients with reduction of pulmonary infections focus was 95.65% (44 cases) in the experimental group, significantly higher than that in the control group(P＜0.05).The cure rate of the experimental group was 58.7%, higher than 32.6% of the control group; the effective rate of the experimental group was 87.0%, significantly higher than the control group(P＜0.05). CONCLUSION The improved postural drainage may facilitate the discharge of sputum of the patients with pulmonary infections after the cardiothoracic surgery, improve the pulmonary ventilation function and boost the curative effect, and it is worthy to be promoted in the hospital.