Abstract: OBJECTIVE To investigate the current status of use of antibiotics by patients with postoperative incision infections in orthopedics department. METHODS From Jan 2014 to Oct 2016, a total of 342 patients who received orthopedic surgery and had postoperative incision infections were enrolled in the study, and the utilization rates of antibiotics were investigated. RESULTS Of the 342 patients with the incision infections, 109 (31.87%) had type Ⅰ incision infections, 152 (44.45%) had type Ⅱ incision infections, and 81 (23.68%) had type Ⅲ incision infections.The antibiotic treatment course was significantly longer in the patients with type Ⅱ incision infections and patients with type Ⅲ incision infections than in the patients with type Ⅰ incision infections (P＜0.05).The medication dosage was significantly higher in the patients with type Ⅲ incision infections than in the patients with type Ⅱ incision infections and the patients with type Ⅰ incision infections (P＜0.05).The utilization rates of two-drug medication and three-drug medication were significantly higher in the patients with type Ⅱ incision infections than in the patients with type Ⅲ incision infections and the patients with type Ⅰ incision infections (P＜0.05).Among the 342 medical records, totally 758 case-times of patients used antibiotics, involving 7 varieties in 4 major categories; the utilization rate of cephalosporins was the highest, totally 425 (56.07%) case-times of patients used cephalosporins, 158 (20.84%) case-times of patients used imidazoles, and 102 (13.46%) case-times of patients used aminoglycosides.Among the patients with incision infections who were not used antibiotics reasonably, 35.09% were the unreasonable usage and dosage, followed by the drug treatment course and medication indications. CONCLUSION Among the orthopedics department patients with postoperative incision infections who used antibiotics, there are the unreasonable medication indications, drug treatment course, usage and dosage, combined drug therapy and medication timing.