Abstract: OBJECTIVE To explore the clinical characteristics of acute obstructive suppurative cholangitis patients complicated with septic shock and investigate the treatment outcomes. METHODS A total of 63 patients with acute obstructive suppurative cholangitis who were treated in the hospital from Mar 2015 to Oct 2016 were recruited as the study objects and given symptomatic therapies such as anti-infection and antishock therapies and then received surgical procedures.The status of operation and incidence of postoperative complications were observed, and the cardiac function, liver function and renal function indexes were compared before and after the treatment. RESULTS Of the 63 patients, 2 had postoperative incision infections, with the infection rate 3.17%; there were 1 (1.59%) case of residual common bile duct stones, 2 (3.17%) cases of complication with multiple organ failure and 2 (3.17%) cases of biliary fistula, and 3 patients died, with the mortality rate 4.76%.The total incidence rate of complications was 15.87%.The mean arterial pressure of the patients was increased more significantly after the treatment than before the treatment, while the heart rate of the patients was decreased more significantly after the treatment than before the treatment(P＜0.05).The levels of liver function indexes alanine aminotransferase, aspartate transaminase and direct bilirubin of the patients were reduced more significantly after the treatment than before the treatment, however, the levels of cholinesterase and albumin of the patients were elevated more significantly after the treatment than before the treatment(P＜0.05).The levels of renal function indexes serum urea nitrogen and serum creatinine of the patients were reduced more significantly after the treatment than before the treatment (P＜0.05). CONCLUSION The acute obstructive suppurative cholangitis patients complicated with septic shock are complicated with fever, abdominal pain, clouding of consciousness, rapid heart rate, reduction of blood pressure, reduction of urine output and symptoms of damaged multiple organs such as aggravation of inflammatory reactions.It is an effective way to conduct the anti-infection, antishock, replenish blood volume and water electrolyte, correct acidosis and carry out surgical procedures so as to control the infections and prevent the liver and kidney organs from damage, with the therapeutic effect remarkable, the incidence of complications low, and it is favorable for the prognosis.