Abstract: OBJECTIVE To explore the clinical characteristics of the male ureteral stent tube indwelling patients complicated with febrile urinary tract infections. METHODS A total of 1236 male patients who were treated with ureteral stent tube indwelling in hospitals from Jun 2013 to Mar 2017 were recruited as the study objects, the patients who were complicated with febrile urinary tract infections were assigned as the infection group, and 100 patients were randomly chosen from the patients without febrile urinary tract infection and set as the non-infection group.The baseline data of the patients were statistically analyzed, the levels of procalcitonin (PCT), C-reactive protein (CRP) and while blood cell counts were compared between the two groups of patients.The urine specimens were collected from the patients with the infections, the isolated pathogens were identified, and the drug susceptibility testing was performed. RESULTS Of the 1236 patients who were treated with ureteral stent tube indwelling, 76 were complicated with febrile urinary tract infections, with the infection rate 6.15%.The levels of CRP, PCT and white blood cell counts were significantly higher in the infection group than in the non-infection group(P＜0.05).Totally 164 strains of pathogens were isolated from the 76 ureteral stent tube indwelling patients complicated with febrile urinary tract infections, of which 120 (73.17%) were gram-negative bacteria, 32 (19.51%) were gram-positive bacteria, and 12 (7.32%) were fungi.The Escherichia coli and Klebsiella pneumoniae were dominant among the gram-negative bacteria; the Enterococcus faecalis and Staphylococcus aureus were the predominant species of gram-positive bacteria.The drug resistance rates of the E.coli and K.pneumoniae strains to imipenem, meropenem, piperacillin-tazobactam, cefoperazone-sulbactam and amikacin were low, and the drug resistance rate to cephalosporins was more than 80.00%. The drug resistance rates of the E.faecalis and S.aureus strains to vancomycin, tigecycline and linezolid were 0, and the drug resistance rates to penicillin G and oxacillin were more than 90.00%. CONCLUSION The CRP, PCT and white blood cell counts can be used as routine examination indexes for diagnosis and prevention of febrile urinary tract infections in the ureteral stent tube indwelling patients.The gram-negative bacteria are dominant among the pathogen isolated from the ureteral stent tube indwelling patients complicated with febrile urinary tract infections.It is necessary to detect the pathogens in a timely manner and carry out the drug susceptibility testing.