Abstract: OBJECTIVE To explore the influence of evidence-based intervention measures on urinary tract infections in patients with indwelling catheterization in department of urology. METHODS A total of 113 patients with indwelling catheterization in department of urology were collected from Feb. 2012 to Oct. 2016, and were randomly divided into control group(56 cases) and observation group(57 cases). After treatment of diseases in department of urology, the two groups of patients were implemented indwelling catheter. The control group was treated with routine intervention, and observation group was treated with evidence-based interventions on the basis of control group. After pulling out the catheter, the patient satisfaction questionnaires were completed. The self rating Anxiety Scale (SAS) score and urodynamics, the incidence of urinary tract infections in different time, catheter indwelling time and the total number of cases of infections and nursing satisfaction of the two groups before and after the intervention were observed. RESULTS There was no significant distinction in SAS score between the two groups before nursing. After intervention, the SAS score of observation group was (19.14±2.35), which was distinctly lower than (39.67±5.91) of control group(P＜0.001). The bladder pressure and urine flow rate of observation group were (51.45±11.36) cmH2O and (10.97±1.89) mL/s, which were significantly higher than (35.21±7.47)cmH₂O and (7.63±1.55)ml/s of control group(35.21±7.47)cmH₂O(P＜0.001). The residual urine volume of observation group was (22.32±4.85) mL,which was significantly lower than (43.78±10.48) mL of control group(P＜0.001).The incidences of urinary tract infections in observation group on the fourth day, eighth day and twelfth day were 0, 3.51% and 5.26%,respectively, which were significantly lower than 19.64%, 25.00% and 30.36% in control group(P＜0.05).The indwelling time of catheter in observation group was (4.21±1.14)days,which was significantly lower than (8.31±3.03) days in control group(P＜0.05).The total incidence of infection in observation group was 5.26%, which was significantly less than 32.14% in control group(P＜0.05). The satisfaction of the patients in observation group was significantly better than that of control group(P＜0.001). CONCLUSION Evidence-based interventions have certain effects on urinary tract infections in patients with indwelling catheter in department of urology,which can ease the anxiety of patients, help patients with recovery of lower urinary tract and bladder function,help to reduce the incidence of urinary tract infections, and improve patient satisfaction with care.