Abstract: OBJECTIVE To observe the significance of dynamic monitoring of serum C-reactive protein (CRP) and (procalcitonin) PCT levels on prevention of bloodstream infection in patients receiving emergency infusion so as to provide new ideas for reduction of incidence of the bloodstream infection. METHODS A total of 124 patients who received emergency infusion in hospitals from Jan 2015 to Jan 2016 were recruited as the study objects and divided into the control group and the experimental group according to the serial number of treatment, with 62 cases in each group.The control group was treated with conventional clinical pathway for management of infusion process so as to prevent the bloodstream infection, while the experimental group, on basis of the treatment of the control group, was given the monitoring of serum CRP and PCT once every 24 hours in the first 3 days after enrollment, followed by the monitoring once every 3 days, and the doctors adjusted the programs for prevention of bloodstream infection based on the results of dynamic monitoring of the CRP and PCT. RESULTS There was no significant difference in the serum CRP or PCT between the two groups of patients at the time of treatment.The levels of serum CRP and PCT of the experimental group showed great changes within one week after enrollment, turned to be relatively high after the enrollment for 24, 48 and 72 hours, reached to the highest after the enrollment for 48 hours and then gradually reduced.The number of times of adjusting the programs for prevention of bloodstream infection was significantly greater in the experimental group than in the control group (P＜0.05).The incidence rate of bloodstream infection of the experimental group was lower than that of the control group within 2 weeks, however, there was no significant between-group difference. CONCLUSION The dynamic monitoring of serum CRP and PCT may facilitate the early diagnosis of bloodstream infections in the patients receiving the emergency infusion so as to take measures, conduct the symptomatic treatment when the infections is not severe, reduce the incidence of bloodstream infection and raise the effective rate of treatment.