Abstract: OBJECTIVE To investigate the effects of L-carnitine adjuvant antibiotics on serum cTnI, procalcitonin and ESR in patients with infective endocarditis. METHODS A total of 42 cases of patients with primary infective endocarditis from May 2014 to Jun. 2016 were selected and randomly divided into control group and L-carnitine group, with 21 cases in each group. Both groups were treated with the basic treatment of oxygen and correction of cardiac function. Patients in control group were given ceftezole sodium and potassium sodium dehydroandroan drographolide succinate, and patients in L-carnitine group were treated more with L-carnitine on the basis of the control group. Changes of serum biochemical parameters, ESR and body temperature and clinical effect were detected. RESULTS Compared with before treatment, the levels of serum cTnI and ESR decreased, the levels of serum PCT, CRP and interleukin -6 (IL-6) decreased, the levels of WBC and MPV decreased in the two groups, and the body temperature decreased with no difference. Levels of cTnI, ESR, PCT, CRP, IL-6, WBC and MPV of L-carnitine group were (1.32±0.16)ng/ml, (13.46±1.72)min, (0.78±0.10)ng/ml, (38.36±5.24)mg/L, (52.34±7.17)mmol/L, (9.43±1.26)×10⁹/L and (8.17±1.12)fl, respectively, which were significantly lower than those of control group (P＜0.001), and the clinical effect of L-carnitine group was significantly better than those of control group (P=0.036). CONCLUSION L-carnitine adjuvant conventional antibiotics has better curative effect in the treatment of infective endocarditis, and it is worthy of further promotion and discussion.