Abstract: OBJECTIVE To analyze the influences of Helicobacter pylori (Hp) infection on motor symptoms and oxidative stress in patients with Parkinson's disease (PD), so as to provide an objective basis for the development of effective clinical treatment. METHODS A total of 85 patients with PD from Jan. 2016 to Dec. 2016 were selected as the case group, which were divided into infection group (71 cases) and non-infection group (14 cases) according to the infection situation, and 80 healthy people were selected as the control group. The infection rate of Hp of the subjects in the two groups were detected and compared. The serum levels of malondialdehyde (MDA) and glutathione reduced (GSH) of the subjects in the two groups were detected and compared. The unified Parkinson's disease rating scale (UPDRS) score of the patients in the case group was evaluated and compared. The "open" time and the "close" time of the patients with the "open-close phenomenon " in the case group were recorded and compared. RESULTS The infection rates of Hp in the case group was 83.53%, which was significantly higher than 60.00% in the control group (P=0.001). The MDA and GSH levels of the subjects in the control group were significantly lower than those in the case group(P<0.05). The serum MDA and GSH levels of the patients with PD complicated with Hp infection were (4.88±0.22)nmol/ml and (0.19±0.01)g/L, which were significantly higher than (4.19±0.21)nmol/ml and (0.18±0.01)g/L of the patients with PD and without Hp infection (P<0.05). The UPDRSⅣ score of the patients with PD complicated with Hp infection was (3.38±0.82), which was significantly higher than (2.72±0.63) of the patients with PD and without Hp infection (P=0.002). CONCLUSION The patients with PD have higher infection rates of Hp. The Hp infection can increase the patient's degrees of motor complications and oxidative stress. The clinicians should give clearance of Hp treatment appropriately in formulating treatment plan in order to improve the therapeutic effects.