Abstract: OBJECTIVE To explore the clinical effect of hydrocolloid dressing and povidone iodine combined with light on wound healing in patients with pressure ulcer infection. METHODS A total of 54 cases of patients with pressure ulcer infection were selected in hospital from Jan. 2015 to Jan. 2017, and were randomly divided into the observation group and the control group, with 27 cases in each group. The control group was treated with povidone iodine combined with light, and the hydrocolloid dressing was used in the observation group. The pathogenic bacteria were analyzed after collecting the specimens, and the clinical efficacy of the two groups of patients was analyzed. RESULTS Among 54 patients with pressure ulcer infection, 67 strains of bacterial pathogenic bacteria were isolated. Among them, 29 strains of gram-negative bacteria accounted for 43.28%, and 38 strains of gram-positive bacteria accounted for 56.72%. The main gram-negative bacteria showed high sensitivity to meropenem and imipenem, and low sensitivity to levofloxacin and gentamicin, and the gram-positive bacteria showed high sensitivity to ciprofloxacin, tetracycline and penicillin, and low sensitivity to levofloxacin and vancomycin. The total efficiency of the observation group was significantly higher than that of control group (P=0.031). CONCLUSION The method of hydrocolloid dressing can promote the wound healing of patients with pressure ulcer infection, which has better clinical effects.