Abstract: OBJECTIVE To investigate the effects of tracheal intubation general anesthesia and epidural anesthesia on the incidence of postoperative abdominal infections, inflammatory factors, immune function and stress response. METHODS A total of 104 cases of patients with elective abdominal surgery in our hospital from Jan. 2012 to Nov. 2015 were selected, and were divided into 2 groups according to the different surgical anesthesia methods, with 52 cases in each group. The control group was treated with tracheal intubation general anesthesia, and the study group was treated with tracheal intubation general anesthesia and epidural anesthesia. The serum IL-1, IL-6, TNF-α, CD₃⁺, CD₄⁺, CD₄⁺/CD₈⁺, cortisol and blood glucose level before anesthesia (T0), 2h after operation (T1) and 1d after operation (T2) were detected, the recovery time, extubation time and postoperative infection of the two groups were recorded. RESULTS Levels of IL-1, IL-6 and TNF-α in serum of T1 and T2 in control group and T1 in study group were significantly higher than those of T0 (P<0.05). Compared with control group, the levels of serum IL-1, IL-6 and TNF-α of T1 and T2in study group were significantly lower (P<0.05). Compared with T0, the serum levels of CD₃⁺, CD₄⁺ and CD₄⁺/CD₈⁺ of T1 and T2 in study group were significantly decreased (P<0.05). Compared with control group, the levels of serum CD₃⁺, CD₄⁺ and CD₄⁺/CD₈⁺ of T1 and T2 in study group were significantly higher (P<0.05). Compared with T0, the serum cortisol and blood glucose of T1 and T2 in control group and T1 in study group were significantly increased (P<0.05). Compared with control group, the serum cortisol and blood glucose of T1 and T2 in study group were significantly lower(P<0.05). The recovery time and extubation time of control group were (15.89±6.52)min and (22.14±8.96)min, which were significantly higher than (9.57±5.67)min and (14.62±7.75)min of study group(P<0.05). The postoperative infection rate of control group was 25.00%, which was significantly higher than 9.62% of study group (P<0.05). CONCLUSION Tracheal intubation general anesthesia combined with epidural anesthesia in patients with abdominal surgery can significantly reduce the incidence of infections, and may be related to the reduction of postoperative inflammatory factors, stress response and improvement of the immune function of the body, with high safety, which is a kind of effective solution.