Abstract: OBJECTIVE To investigate the status of nosocomial infections and the related factors of infections in patients with depression. METHODS A total of 198 patients with depression treated in hospital from Jan. 2013 to Jan. 2015 were selected as the research objects. Specimens of pus, blood, urine and sputum were collected for bacterial identification and drug sensitivity tests, and related factors of nosocomial infections in patients with depression were analyzed. RESULTS There were 17 cases of nosocomial infections, and the infection rate was 8.59%. Totally 20 strains of pathogenic bacteria were isolated from infected patients, of which 8 strains were gram-positive bacteria accounting for 40.00%, 11 strains were gram-negative bacteria accounting for 55.00%, and 1 strain was fungi accounting for 5.00%. Drug susceptibility tests results showed that main gram-positive bacteria were highly resistant to penicillin G and erythromycin, and more sensitive to vancomycin and linezolid, and main gram-negative bacteria had high resistant rate to ampicillin, and were susceptible to cefoperazone/sulbactam, imipenem and meropenem. Pseudomonas aeruginosa and Klebsiella pneumoniae were sensitive to levofloxacin. Age ≥60 years old, with underlying diseases, length of stay ≥25d, broad-spectrum antimicrobial drug use, invasive procedures, no awareness of prevention of infection, imperfect nosocomial infection management system, more severe depression, and use of 2 or more antidepressants were related factors for nosocomial infections in patients with depression(P＜0.05). CONCLUSION Gram-negative bacteria are the main pathogens of nosocomial infections in depressive patients. There are many factors that cause nosocomial infections. Corresponding measures should be taken according to relevant factors to reduce the incidence of nosocomial infections in depressive patients.