Abstract: OBJECTIVE To evaluate the effect of management by objectives in the prevention of intraoperative and postoperative pressure ulcer infection in patients undergoing surgery. METHODS A total of 468 patients who underwent surgical treatment from Jan. 2016 to Dec. 2016 were selected as experimental group, and 404 patients who underwent surgical treatment from Jan. 2015 to Dec. 2015 were selected as the control group. The control group of patients were received conventional pressure ulcer prevention methods, and patients in observation group were implemented the management by objectives pressure ulcer prevention methods. The incidence of pressure ulcer, pressure ulcer site and pressure ulcer staging of the two groups were recorded. The dispute rate between nurses and patients, nursing complaint rate and family satisfaction rate of the two groups were recorded. The infection rates of the two groups of patients infected with pressure sores were recorded, and samples of patients with pressure ulcer infection were collected for pathogen identification. RESULTS The incidence of pressure ulcer in the experimental group was 2.56% (12/468), which was significantly lower than 9.41%(38/404) in the control group (P=0.029), and there was a significant difference between the two groups in the pressure ulcer stage (P=0.035). The family satisfaction rate of the experimental group was 97.22% (455/468), which was significantly higher than 71.53%(289/404) of the control group (P＜0.001), the dispute rate between nurses and patients was 1.71% (8/468), and the nursing complaint rate was 2.14% (10/468) in the experimental group, which were significantly lower than 5.45% (22/404) and 6.44% (26/404) in the control group (P＜0.05). Of the 50 patients with pressure ulcer, 14 had infection. A total of 20 strains of pathogenic bacteria were detected, of which 12 strains of gram-positive bacteria accounted for 60.00%, mainly Pseudomonas aeruginosa, and 8 strains of gram-negative bacteria accounted for 40.00%, mainly Staphylococcus aureus. CONCLUSION Management by objectives can help to reduce the incidence of intraoperative pressure ulcer, reduce the dispute rate between nurses and patientsand the rate of nursing complaints, and improve the satisfaction rate of family members, which is a feasible method for prevention and management of intraoperative pressure ulcer.