Abstract: OBJECTIVE To explore clinical effects of team cooperation combined with risk prevention intervention on nosocomial infection in emergency children. METHODS A total of 168 patients of emergency children with nosocomial infection from Sep. 2016 to Dec. 2016 in our hospital were selected as the research objects, and were divided into intervention group and control group, with 84 cases in each group. Patients in control group were received conventional nursing intervention, and patients in intervention group were treated with team cooperation combined with risk prevention emergency hospital management of nursing intervention. The risk events of grade I, II and III in the nursing process were statistically calculated and the total numbers of risk events of the two groups were calculated. The patient satisfaction of team cooperation combined with risk prevention was scored, including nursing score, life nursing score, psychological nursing score and risk events and processing speed score and the safety guarantee score(falling out of bed, choking, etc.). Finally, the incidence of nosocomial infection was statistically analyzed. RESULTS The life nursing score, psychological nursing score and therapeutic nursing score of the intervention group were (8.99±2.34), (9.23±3.02), and (9.12±3.11), respectively, which were significantly higher than those in the control group (P<0.05). Different degrees of risk events were occurred in both groups in the nursing management process. The grade I, II and III risk events in intervention group were 2 cases, 9 cases and 11 cases, which were less than those in the control group. The number of total risk events in the intervention group was 22 cases, which was significantly less than 39 cases of the control group (P =0.025). The satisfaction scores of therapeutic nursing, life nursing, psychological nursing, risk treatment and safety guarantee of the intervention group were (4.23±1.11), (4.71±1.46), (4.35±1.33), (9.25±3.10) and (8.92±2.89), which were significantly higher than those of the control group (P<0.05). There were 12 cases of nosocomial infection in the intervention group, which were significantly less than 28 cases in the control group (P=0.046). Totally 20 strains of pathogenic bacteria were detected in the intervention group, and 22 strains were detected in the control group. CONCLUSION Team cooperation combined with risk prevention intervention is more effective than the conventional management nursing intervention, which can improve the team cooperation ability, improve the management and nursing quality, and reduce the nosocomial infection rate of emergency children.