Abstract: OBJECTIVE To discuss the correlation of serum N-terminal brain natriuretic peptide (NT-proBNP) and inflammatory factorsProcalcitonin (PCT), C-reactive protein (CRP), interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α(TNF-α) in patients with heart failure complicated with pulmonary infection with cardiac function. METHODS A total of 228 cases of heart failure patients in hospital from Mar. 2014 to Mar. 2017 were selected as the research objects, and were divided into infection group (86 cases) and non-infection group (142 cases) according to whether there had pulmonary infection. A total of 112 cases of healthy physical examination in the same period were set as control group. Serum enzyme profileaspartate aminotransferase(AST), lactate dehydrogenase(LDH), creatine kinase(CK) and creatine kinase MB(CKMB) were measured by enzyme coupling, NT-proBNP, CRP, PCT, and levels of IL-1β, IL-6 and TNF-α were detected, and their correlationwith cardiac function was analyzed. RESULTS Serum levels of AST, LDH, CK, CKMB, NT-proBNP, PCT, CRP, IL-1β, IL-6 and TNF-α in heart failure group were significantly higher than those in control group (P<0.05). Serum levels of NT-proBNP, PCT, CRP, IL-1β, IL-6 and TNF-α in infection group were (13.36±5.96)μg/L, (8.97±4.66)μg/L, (11.32±5.82)mg/L, (9.82±6.06)μg/L, (18.31±6.95)μg/L and (10.35±4.63)μg/L, which were significantly higher than those in non-infection group (P<0.05), while no significant differences was observed in AST, LDH, CK, CKMB between the above two groups. NT-proBNP, PCT, CRP, IL-1β, IL-6 and TNF-α were significantly correlated with AST, LDH, CK, CKMB in infection group(P<0.05). Serum levels of NT-proBNP, PCT, CRP, IL-1β, IL-6 and TNF-α in New York Heart Association (NYHA)classification Ⅲ and Ⅳ grades group were significantly higher than those in NYHA Ⅰ and Ⅱ grade groups (P<0.05). CONCLUSION NT-proBNP, PCT, CRP, IL-1β, IL-6 and TNF-α are increased in heart failure patients complicated with pulmonary infection, and can reflect cardiac function and pulmonary infection, which has important clinical significance.