Abstract: OBJECTIVE To observe the clinical effect of cefuroxime combined with levofloxacin on treatment of patients with urinary tract infections. METHODS A total of 288 patients who were hospitalized the urology department from Dec 2015 to Dec 2016 were recruited as the study objects, the prevalence of urinary tract infections was statistically analyzed, the patients with urinary tract infections were treated with cefuroxime combined with levofloxacin, the comprehensive therapeutic effect was observed, and the levels of serum and urine interleukins (IL) and tissue factors(TF) were compared before and after the treatment. RESULTS Of the 288 patients, 56 had urinary tract infections, with the infection rate 19.44%.Among the 56 patients with infection, 38 were cured after the treatment, 10 were improved, 7 were effective, 1 was ineffective, and the total effective rate of treatment was 98.21%.All of the patients did not have adverse reactions.The levels of serum and urine IL-4, IL-6, IL-8, IL-12 and TF of the patients with infection were significantly reduced after the treatment (P＜0.05). CONCLUSION Cefuroxime combined with levofloxacin can achieve remarkable clinical effect on treatment of the patients with urinary tract infections. The levels of serum and urine interleukins and levels of inflammatory factors are significantly improved.