Abstract: OBJECTIVE To detect pathogens and analyze risk factors for bacteraemia in patients with stage Ⅲ~Ⅳ pressure ulcers (PUs) so as to provide guidance for clinical treatment. METHODS A total of 136 patients with stage Ⅲ~Ⅳ PUs in ICU from Sep.2012 to Nov.2016 were selected, and were divided into two groups according to whether the bacteraemia occurred: bacteraemia group (n=72) and control group (n=64). Pathogens and other relevant clinical information were detected and recorded. The factors associated with bacteraemia in patients with stage Ⅲ~Ⅳ pressure ulcers were summarized. RESULTS Of the 136 patients with stage Ⅲ~Ⅳ PUs, 72 cases had bacteraemia, with the infection rate of 52.94%. Totally 72 strains of pathogens were isolated, including 39 strains of gram-negative bacteria (54.17%) mainly Escherichia coli, and 33 strains of gram-positive bacteria (45.83%), mainly Staphylococcus aureus. The main gram-negative bacteria were sensitive to imipenem and meropenem, and the main gram-positive bacteria were sensitive to linezolidand and vancomycin. The age, endotracheal catheter, use of antibiotics≥ 3 kinds and serum PCT were risk factors of bacteraemia in patients with stage Ⅲ~Ⅳ pressure ulcers(P＜0.05). CONCLUSIONS Patients with stage Ⅲ~Ⅳ PUs are prone to bacteraemia and the drug resistant rates are high. Sensitive antibiotics should be selected for treatment, and corresponding measures should be taken to improve the prognosis of patients.