Abstract: OBJECTIVE To investigate the effect of interventional mode of intervention in emergency intensive care unit (EICU) and prevention of infection in patients with large area myocardial infarction and cardiac arrest. METHODS The clinical data of 112 patients with large area myocardial infarction complicated with cardiac arrest treated in hospital from Feb. 2016 to May 2017 were retrospectively analyzed, and were divided into study group and control group according to different nursing methods, with 56 cases in each group. Patients in control group were given routine nursing intervention, and in study group were given targeted nursing intervention. The resuscitation success rate, infection rate, respiration and heartbeat recovery time, quality of life and complications between the two groups were compared. RESULTS The resuscitation success rate in study group was 92.86%, which was higher than 76.79% in control group, and there were no infected patients in study group, and 6 cases of infected patients in control group (P<0.05). The recovery time of respiration and heartbeat in study group were (4.52±0.83) min and (15.62 ± 2.28 ) min, which were shorter than (7.63±1.24) min and (22.18±3.80) min in control group (P<0.001). After intervention, scores of SF-36 in both groups were increased, and the scores of study group were better than those of control group (P<0.05). There were 3 cases of complications in study group, which were less than 10 cases in control group (P<0.05). CONCLUSION The implementation of EICU targeted intervention in patients with large area myocardial infarction complicated with cardiac arrest can effectively improve the success rate of rescue, reduce the infection rate, promote respiration and heartbeat recovery, reduce the incidence of complications and improve the quality of life.