Abstract: OBJECTIVE To explore the risk factors and intervention methods of periprosthetic infections in patients with total hip arthroplasty. METHODS A total of 306 patients with total hip arthroplasty in the hospital from Jan. 2010 to Dec. 2016 were enrolled in this study. The clinical symptoms, such as body temperature, joint pain and changes of inflammatory markers were compared with the use of antibacterials, gender, time of surgery, age, history of hormone use, obesity, immunological diseases, diabetes and so on. RESULTS There were 19 cases of periprosthetic infections in 306 patients, and the incidence rate was 6.21%. Totally 23 strains of gram-positive bacteria were cultured and isolated, mainly Staphylococcus aureus. The use of antibacterial drugs, operation time, immunological disease, diabetes and hormone were the factors associated with infections (P<0.05). The neutrophil count, patients after treatment (Harris), erythrocyte sedimentation rate, visual analogue scale (VAS), C- reactive protein and white blood cell counts of patiens after treatment were (57.20±5.13)%, (93.06±4.98)points, (17.24±4.53)mm/h, (4.99±2.08)points, (10.28±1.34)mg/L and (8.06±2.05)×10⁹/L, which had significant differences compared with those before treatment (P<0.05). After treatment, 4 cases were improved and 15 cases were cured. CONCLUSION The clinical symptoms of periprosthetic infections after artificial joint replacement are obvious, and were related to the patient's own diseases, the use of antibiotics and the time of operation. In the treatment, patients should be combined with their own situations to reduce the drug treatment and operation time, especially to take control measures on critically ill patients to reduce the incidence of periprosthetic infections.