Abstract: OBJECTIVE To analyze the distribution and risk factors of nosocomial infection in patients with cerebrovascular disease after interventional treatment, and to summarize prevention strategies. METHODS The clinical data of 108 patients with cerebrovascular disease who underwent interventional therapy in our hospital from Jan. 2015 to Apr. 2017 were retrospectively analyzed. After the interventional treatment of patients, the infection status as well as the types and drug resistance of pathogens in patients with nosocomial infection was studied. The clinical data of patients were analyzed, and the risk factors of nosocomial infection after interventional therapy in patients with cerebrovascular disease were summarized. RESULTS In 108 patients with cerebrovascular disease, 21 cases of nosocomial infection occurred after interventional therapy, the infection rate was 19.44%. The infections were dominated by bloodstream infection, respiratory infection and genitourinary infection. 30 strains of pathogens were isolated and cultured, of which there were 20 strains of gram-negative bacteria accounting for 66.67%, 6 strains of gram-positive bacteria accounting for 20.00%, and 4 strains of fungi accounting for 13.33%. Multivariate logistic regression analysis showed that basic diseases, tracheal intubation and indwelling catheter were risk factors for nosocomial infection after interventional therapy in patients with cerebrovascular disease (P<0.05). CONCLUSION The patients with cerebrovascular disease have a relatively risk of nosocomial infection after interventional therapy. The medical staff should take appropriate preventive measures based on the risk factors of nosocomial infection, so as to reduce the incidence of nosocomial infection in patients during interventional therapy.