Abstract: OBJECTIVE To explore the risk factors for peripherally inserted central venous catheter (PICC)-related infection after gastrointestinal surgery and observe the advantages and disadvantages of the three types of fixation methods. METHODS From Jan 2012 to Oct 2016, a total of 305 patients who were treated with PICC after the gastrointestinal surgery were recruited as the study objects and divided into the adhesive tape fixation group (group A) with 110 cases, the sutured fixation group (group B) with 105 cases and the Sirol buckle fixation group with 90 cases (group C) according to the fixation method of PICC. The incidence rates of displacement/prolapse, adverse reactions and pain score were observed and compared among the three groups, the patients who had the PICC-related infection were statistically analyzed, and the univariate analysis and multivariate logistic regression analysis were performed for the PICC-related infection. RESULTS There were no significant differences in the rate of displacement of catheter, distance of displacement, number of times of displacement and rate of prolapse of catheter among the three groups.The incidence of skin allergy was significantly lower in the group A and the group B than in the group C (P<0.05). The pain score of the group B was significantly higher than that of the group A and the group C, and the pain score of the group C was significantly higher than that of the group A (P＜0.05). The result of the logistic regression analysis indicated that the displacement of catheter, immune function, maintenance cycle of catheter and puncture technique were the risk factors for the PICC-related infection (P＜0.05). In terms of the effectiveness of fixation, the sutured fixation method had obvious advantages; in terms of the safety of fixation, the adhesive tape fixation was obviously superior to the other two fixation methods; in terms of the experience of fixation, the Sirol buckle fixation was better. CONCLUSION It is an effective way to prevent the displacement of catheter, boost the immune function of the patients, maintain the catheter in a timely manner and improve the puncture technique so as to reduce the incidence of catheter-related infection. The adhesive tape fixation can achieve the most remarkable effect.