Abstract: OBJECTIVE To explore the feasibility and safety of fast track surgery (FTS) concept in the lung cancer surgery. METHODS A total of 100 lung cancer patients who were supposed to received surgical procedures were recruited as the study objects and randomly divided into the study group and the control group, with 50 cases in each group. The study group was treated with FTS concept during the perioperative period, while the control group was treated with conventional treatment mode. The incidence rates of complications such as postoperative infection, postoperative length of hospital stay, chest tube indwelling time and visual analogue scale (VAS) were observed and compared between the two groups of patients. The levels of serum C-reactive protein (CRP) were compared before the surgery and after the surgery for 1, 3 and 5 days. RESULTS The incidence rates of postoperative infectious complications (pulmonary infection, incision infection) of the study group were significantly lower than those of the control group (P＜0.05); the total incidence of postoperative complications of the study group was significantly lower than that of the control group (P＜0.01). The serum PCT levels of the two groups of patients were significantly higher after the surgery for different time periods than before the surgery (P＜0.01). The serum CRP levels of the study group were significantly lower than those of the control group after the surgery for 1, 3 and 5 days (P＜0.01). The postoperative length of hospital stay and chest tube indwelling time were significantly shorter in the study group than in the control group (P＜0.01). The VAS scores of the study group were significantly lower than those of the control group after the surgery for different time periods(P＜0.01). CONCLUSIONS FTS concept may significantly reduce the incidence of postoperative complications such as infections in the lung cancer patients during perioperative period, shorten the length of hospital stay, alleviate the pain and promote the rehabilitation of the patients.