Abstract: OBJECTIVE To explore the relationship between the infection-related factors and the phenotypes of chronic obstructive pulmonary disease (COPD). METHODS Totally 120 patients with COPD who were treated in the hospital from Feb 2015 to Apr 2017 were assigned as the COPD group, meanwhile, 120 healthy people who received physical examination were set as the control group. The COPD patients were divided into subgroups according to the disease course, illness condition and result of HRCT. The levels of serum interleukin-32 (IL-32) andprocalcitonin (PCT) were detected by using ELISA, the level of serum high-sensitivity C-reactive protein (hs-CRP) was determined by means of immediate immunochromatography, the lung function was detected by using lung function test system; the forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1) and ratio of FEV1 to FVC of the patients were observed after the intake of bronchodilators. The correlation between the levels of peripheral blood IL-32, hs-CRP, PCT and the lung function indexes was analyzed. RESULTS The levels of serum IL-32, hs-CRP and PCT of the COPD group were significantly higher than those of the control group (P＜0.05). The FEV1, FVC and ratio of FEV1 to FVC of the COPD group were significantly lower than those of the control group (P＜0.05). There were significant differences in the levels of IL-32, hs-CRP and PCT among the patients with different types of COPD (P＜0.05). The severer the illness condition of the COPD patients, the higher the levels of serum IL-32, hs-CRP and PCT were; the IL-32 level of the patients with emphysema type COPD was highest, followed by the patients with mixed type of COPD, the patients with trachitis type COPD lowest; the levels of hs-CRP and PCT of the patients with mixed type of COPD were the highest, followed by the patients with trachitis type COPD, the patients with emphysema type COPD the lowest, and there were significant differences (P＜0.05). The result of correlation analysis showed that the levels of peripheral blood IL-32, hs-CRP and PCT of the COPD patients were negatively correlated with the FEV1, FVC and ratio of FEV1 to FVC (P＜0.05). CONCLUSIONS The upregulated expression of the infection-related factors shows certain correlation with the severity and classification of COPD as well as the decline of lung function.