Abstract: OBJECTIVE To explore the influence of case intervention on behaviors of homosexual behavior patients with HIV infection. METHODS A total of 114 patients with HIV infection who were firstly diagnosed in the hospital from Mar 2016 to Mar 2017 were recruited as the study objects and randomly divided into the control group and the study group with 57 cases in each group, all of the patients were male homosexual sex. The control group was treated with conventional therapy and interventions, including psychological intervention, cognition intervention and behavioral intervention, while the study group was given the case intervention on basis of the treatment of the control group. The use of condoms and fixation of sexual partners of the two groups of patients were recorded before and after the intervention, and the medication compliance was observed and compared between the two groups of patients. RESULTS The use of condoms of the study group was significantly better than that of the control group after the case intervention was carried out (P＜0.05). The fixation of sexual partners of the study group was significantly better than that of the control group after the case intervention was carried out (χ²=4.275,P=0.041). The medication compliance of the study group was significantly better than that of the control group after the case intervention was carried out (χ²=4.689,P=0.037). CONCLUSIONS The case intervention may effectively raise the utilization rate of condoms and fixation rate of sexual partners as well as the medication compliance of the homosexual behavior patients with HIV infection, and it plays positive role in improving the behavioral pattern of the patients and is worthy to be promoted in the hospital.