Abstract: OBJECTIVE To explore the influencing factors and pathogenic characteristics of nosocomial infection after intracranial interventional therapy for aneurysms. METHODS The clinical data of 680 patients who underwent interventional treatment of intracranial aneurysms in hospital from May 2014 to Sep.2017 were retrospectively analyzed.The incidence of nosocomial infection after treatment was analyzed.The pathogenic characteristics of infected patients were analyzed.The clinical data of age, smoking history, indwelling gastric tube, white blood cell count, serum albumin level and blood glucose level were analyzed by univariate analysis, and multivariate logistic regression was used to analyze the influencing factors of nosocomial infection. RESULTS Among the 680 patients enrolled, 122 cases of nosocomial infection occurred, and the infection rate was 17.94%.In the distribution of infection sites, pulmonary infection was the main cause, with 62 cases accounting for 50.82%, followed by urinary tract infection, with 25 cases accounting for 20.49%.In the 122 cases of infected patients, 138 strains were isolated by bacteriological examination, including 97 strains of gram-negative bacteria, accounting for 70.29%, 26 strains of gram-positive bacteria accounting for 18.84%, and 15 strains of fungi accounting for 10.87%.Multivariate logistic regression analysis showed that age ≥ 65 years old, indwelling gastric tube, smoking history, elevated white blood cell count, low albumin and low GCS scores were the influencing factors of nosocomial infection (P＜0.05). CONCLUSION For patients after aneurysm interventional therapy, there are many influencing factors of nosocomial infection.Targeted preventive measures should be taken, and antibiotics should be rationally selected to reduce the incidence of nosocomial infection.